What is Unipolar Depression? Symptoms, Causes, and Treatments 

Unipolar depression, known as major depressive disorder, is a condition that causes people to feel extremely low or sad for at least two weeks at a time. This condition can be debilitating, preventing those who are affected by it from carrying out day-to-day tasks and activities.   

Unipolar depression is a common mental health disorder in the U.S. It’s vital to recognize its symptoms and seek help. This will foster healthier communities. This condition is often compared with bipolar depression as their names are very similar. The key difference is that bipolar depression has emotional highs (mania) and lows. Unipolar depression consists mainly of depressive episodes.  

What is Unipolar Depression?  

Unipolar depression causes a low mood, loss of energy, disinterest, and low self-esteem overall. This condition can make work, school, and daily activities feel nearly impossible.   

Unipolar depression is just one subtype of depression. There are several types of depression that vary based on duration, severity, and triggers. Common types include:  

  • Persistent Depressive Disorder  
  • Seasonal Depressive Disorder   
  • Postpartum Depression  

Bipolar depression is not listed above as this term is often used to describe bipolar disorder. For those with bipolar disorder, these periods of depression often alternate with periods of mania.   

Symptoms of Unipolar Depression  

The symptoms of unipolar depression have broad-reaching impacts on a person’s life. Because depressive episodes come and go, it can be helpful to keep a journal to track these feelings. Symptoms of unipolar depression include:   

Emotional Symptoms:   

  • Sadness   
  • Low self-esteem  
  • Thoughts of death or suicide   

Physical Symptoms:  

  • Changes in sleeping patterns  
  • Weight loss or gain  
  • Low energy  

Cognitive Symptoms:  

  • Lack of interest in tasks and activities  
  • Difficulty concentrating   

Causes of Unipolar Depression  

As with many mental health disorders, there is no known cause of unipolar depression. However, there are several factors that are thought to contribute to the development of this condition including:   

  • Biological factors: While more research is needed, studies show that differences in the brain’s structure and chemistry may be correlated to depression. Those with a family history of depression are also at a higher risk of developing the condition.   
  • Psychological factors: Co-occurring mental health conditions and personality traits like self-criticism are thought to contribute to the development of depression.   
  • Environmental factors: Traumatic life events, serious illness, and substance use are also believed to be factors.   

Like many mental illnesses, major depressive disorder can cause social withdrawal. However, it’s important that those with this condition build and maintain a strong support group.   

How is Unipolar Depression Diagnosed?  

If you or a loved one has symptoms of unipolar depression, the first step is to see a family or primary care doctor for bloodwork. This will rule out any physical health complications as a potential cause.  

After physical conditions have been addressed, the next step is often a referral to a mental health professional. Next, a therapist, psychiatrist, or psychologist will administer some tests. These are validated questionnaires, like the PHQ-9. They will check for depression and the severity of symptoms.  

Seeking professional help is important to streamline the diagnosis process and access help as quickly as possible.   

Unipolar Depression vs. Bipolar Depression  

As their names suggest, unipolar depression and bipolar depression share many characteristics – but they also differ in several ways.  

Unipolar depression usually means a drop from one’s baseline to feeling very low. Bipolar depression is a term often used to describe bipolar disorder. People with bipolar disorder typically experience extreme highs and lows, alternating between both ends of the emotional spectrum.   

These are fundamentally two different mood disorders with different needs for proper treatment and management. Because of this, an accurate diagnosis that differentiates between the two conditions is key.   

Treatment Options for Unipolar Depression   

Fortunately, there are a variety of treatment options available for those with unipolar depression. With the help of a healthcare provider, those with this condition can explore treatments and lifestyle changes to find the combination that provides them with the best results.   

Some treatment options to consider are:  

  • Psychotherapy: Talk therapy, such as cognitive-behavioral therapy (CBT), helps individuals identify and process negative emotions while developing healthier coping mechanisms.  
  • Medications: Some people with unipolar depression benefit from taking antidepressants in addition to participating in therapy. Many well-studied medications exist. A trained physician will help patients find the best medication and dosage.  
  • Lifestyle Changes: Everyone can benefit from following a self-care routine. This can include journaling to track emotions, yoga and mindfulness to enhance the mind-body connection, and maintaining a balanced diet.   
  • Emerging Treatments: There are a number of new treatments emerging in the mental health space. Some of these options for depression treatment include transcranial magnetic stimulation (TMS) and esketamine, often referred to by the brand name Spravato.  

Living with Unipolar Depression  

Unipolar depression impacts millions of Americans each year. Living with this condition comes with its own set of challenges, but with a support system and helpful coping mechanisms, this condition can be managed. A strong support system can uplift and encourage those who are struggling with depression, helping them to find and access additional help if needed.  

It’s also helpful for those with this condition to develop a toolkit of coping strategies that they can turn to. Strategies can include:  

  • Breathing and grounding techniques  
  • Having someone to call in times of high stress or emotional lows  
  • Participating in a relaxing hobby  

When to Seek Help for Unipolar Depression  

If you or someone you love has experienced extended periods of sadness or a low mood, remember that help is available and that there are many treatment options for depression. As with all mental health disorders, seeking help early on can greatly improve treatment outcomes.  

If you or a loved one is experiencing a mental health crisis, call or text 988 or visit: https://988lifeline.org/ for support.      

SunCloud Can Help

At SunCloud, we specialize in treating mood disorders including major depressive disorder. Unipolar depression impacts millions of people each year, but no one has to suffer alone. Mental health conditions can be managed with the right combination of expert help and evidence-based therapies.   

If you believe that you or a loved one may be suffering from unipolar or bipolar depression, contact the team at SunCloud today.   

Rachel Collins, LCSW
Site Director of Northbrook PHP and IOP

Rachel Collins, LCSW, is the Site Director of SunCloud Health’s Northbrook Partial Hospitalization (PHP) and Intensive Outpatient (IOP) programs for both adolescents and adults. Rachel earned her bachelor’s degree in psychology and went on to complete her master’s degree in social work from Michigan State University. She has since worked in a wide range of settings, including inpatient treatment, PHP/IOP programs, therapeutic group homes, and private practice. Rachel specializes in treating trauma (using Cognitive Processing Therapy) and anxiety, practicing through a relational, compassionate, and client-centered lens. She is passionate about creating a therapeutic space in which clients feel safe and able to explore various parts of themselves with curiosity as opposed to judgement. In addition to her leadership and clinical work, she is passionate about creating art, and learning about the intersection between creativity and mental health.

Kayla Corirossi, MA, LCSW
Site Director, Naperville PHP/IOP (Adolescents & Adults)

Kayla Corirossi, MA, LCSW, is the Site Director of SunCloud Health’s Naperville Partial Hospitalization (PHP) and Intensive Outpatient (IOP) programs for adolescents and adults. She brings extensive experience working with individuals across the lifespan, including adolescents, adults, and geriatric populations, and specializes in the treatment of mood disorders, trauma, substance use, family systems, forensic populations, and individuals in crisis.

Kayla has worked in a wide range of clinical and community settings, including community-based interventions, police crisis response, correctional facilities, inpatient treatment, PHP/IOP programs, and with vulnerable and underserved populations. In addition to her clinical and leadership work, she is passionate about providing mental health education and advocacy within the community.

Kayla earned her Bachelor’s degree with a double major in Psychology and Sociology from Aurora University and went on to complete her Master’s degree in Forensic Social Work, also at Aurora University. Her clinical approach is evidence-based, compassionate, trauma-informed, and integrative, emphasizing collaboration and individualized care.

Driven by a personal mission to meet individuals where they are, Kayla is committed to helping clients feel safe, supported, and understood. She strives to create a natural and empathetic healing environment while ensuring individuals from all backgrounds and identities know they are not alone and have access to meaningful resources and support.

Elizabeth E. Sita, MD
Medical Director of Adult Services
Dr. Elizabeth E. Sita, MD, is a Board Certified psychiatrist specializing in the care of patients with eating disorders. She completed her undergraduate training at the University of Chicago and graduated with Highest Honors. She then earned her medical degree at Northwestern University Feinberg School of Medicine and was recognized with the Chairman’s Award for Excellence in Psychiatry. She subsequently completed residency with the Department of Psychiatry and Behavioral Sciences at McGaw Medical Center of Northwestern University, where she was elected Chief Resident and received the Resident Psychiatrist Leadership & Service Award. Upon completing her training, Dr. Sita came to Ascension Alexian Brothers Behavioral Health Hospital, where she served as Assistant Medical Director of the Center for Eating Disorders and Director of Transcranial Magnetic Stimulation Services before transitioning to lead the new inpatient eating disorder unit as Medical Director of Eating Disorder Services at Ascension Saint Joseph Hospital – Chicago. In these roles, she has cared for a multitude of adolescents and adults struggling with anorexia nervosa, bulimia nervosa, binge eating disorder, and other eating disorders as well as severe, cooccurring mood, trauma, personality, and substance use disorders. Dr. Sita has been recognized throughout her training and practice for a commitment to excellence in patient care and for her ability to engage patients in their most challenging moments. Her passions include the care of treatment-resistant eating and mood disorders as well as questions of medical capacity and end-of-life decision making. She believes that, first and foremost, human connection is key to mental health and well-being and strives to share this philosophy in each and every patient encounter. She is excited to bring her expertise to SunCloud Health as the Medical Director of Adult Services!   VIDEO: Meet Elizabeth E. Sita, MD, Medical Director of Adult Services  
Lacey Lemke, PsyD
Assistant Vice President of Clinical Services

Dr. Lacey Lemke (she/her) is a licensed clinical health psychologist with specialized expertise in the treatment of eating disorders and the practice of medical and health psychology. She completed her doctoral training in clinical psychology with a Primary Care emphasis at the Adler School of Professional Psychology. Dr. Lemke went on to complete both her predoctoral clinical internship and postdoctoral fellowship through Ascension Health, where she gained advanced training working with individuals experiencing eating disorders and self-injurious behaviors, as well as within pediatric subspecialty settings including endocrinology, neurology, and adolescent medicine.

Dr. Lemke is deeply committed to providing evidence-based, compassionate care and collaborates closely with interdisciplinary teams to ensure comprehensive treatment. Her professional mission is to support patients in achieving their fullest potential by guiding them to the most appropriate level of care and empowering them to make meaningful, sustainable progress toward improved health and well-being.

VIDEO: 2. Meet Lacey Lemke, PsyD.